Why do some people do not feel cold?

February 19, 2021
Loss of actin 3 is caused by loss of function (LOF) in the ACTN3 gene, and is becoming more common as more people move to cooler environments. Loss of actin 3 is caused by loss of function (LOF) in the ACTN3 gene, and is becoming more common as more people move to cooler environments.

Dubai United Arab Emirates:- Researchers at the Karolinska Institute in Sweden conducted the unveiling, the study included 32 healthy men between the ages of 18 and 40 years, which proved that one-fifth of the world's population have "super resilience" with low temperatures, due to the presence of a genetic mutation, where they do not feel cold at all.

The study sample sat in 14 ° C water, until their body temperature dropped to 35.5 ° C.

The researchers measured the electrical activity of the muscles and took muscle biopsies from the volunteers to study their protein content and fiber composition.

According to the results, the α-actinin-3 protein, which is found in the "fast twitch fibers" inside the muscles, is absent in 20% of people, and its absence makes them better at maintaining temperature.

The study showed that without the protein there are slow-twitch muscle fibers. This indicates that the type of low-intensity continuous activation present in this variant of the faster version of muscle fibers is more effective in generating heat.

And the team that prepared the study suggested that this genetic variant may have protected modern humans from the cold when they migrated from Africa more than 50,000 years ago.

And based on the study; The team believes that about 1.5 billion people worldwide will carry this variant, increasing their tolerance to cold climates.

The results indicated that this is due to the lack of "actinin 3", which enhances cold tolerance by increasing the tension of their muscles, and leads to more slow muscle twitching.

When immersed in cold water during the experiment, people who had the swing had increased muscle tone rather than twitching.

About 1.5 billion people around the world carry the ACTN3 LOF variant, today, and therefore lack actinin 3.

Although this protein deficiency is not associated with muscle disease, it impairs performance during strength and jogging activities.

The change became more prominent as humans began to move to colder climates - which the researchers use as an argument for why it improved tolerance of the cold.

On average, the loss of α-actinin-3 reduced the average temperature in the rectum and calf by half.

People who had the replacement showed a shift towards slow-twitch muscle fibers. This caused an increase in muscle tone instead of twitching during immersion.

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