Mohammed Omar al-Mukhtar was born in 1921 in Al-Awailiya, near al-Marg in the east of Libya. He lived with his mother, Naisa al-Gilani and some of his relatives.
He left Libya with his mother to Egypt in 1927, at the request of his father Omar al-Mukhtar, who wanted to devote himself to fighting the Italian occupation forces.
Mohammed lived in Egypt for 18 years in the city of Hammam, and moved between the cities of Sidi Barani, Matrouh, Alexandria and others.
Omar al-Mukhtar's son is educated at the Shatby School in the coastal city of Alexandria, where he was informed of the execution of his father by the occupation forces.
Mohammed married twice, the first of his cousin, Azza al-Fayoumi in 1942, did not have children, and then died.
In 1964, he married Fatima Ghariani, and had children of her who died young, to remain the only one carrying the descendants of Omar Mukhtar, after the death of his brother and all of his relatives.